EGFR Products

Antibodies
EGFR Antibody [Unconjugated]
EGFR Antibody [Unconjugated]
AF231
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
EGFR Antibody [Unconjugated]
EGFR Antibody [Unconjugated]
AF1280
Species: Mu
Applications: WB, Simple Western, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
EGFR [p Tyr1173] Antibody [Un ...
EGFR [p Tyr1173] Antibody [Unconju...
Species: Hu
Applications: WB, Simple Western, IHC, CyTOF-ready, Flow, ICC/IF
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
ELISA Kits
Human EGFR [p Tyr1086] ELISA ...
Human EGFR [p Tyr1086] ELISA Kit
KA2159
Species: Hu
Applications: ELISA
Kits
EGFR Isolation Kit
EGFR Isolation Kit
MAGH124-NOV
Species: Hu
Applications: Flow
Lysates
EGFR Knockout HeLa Cell Lysat ...
EGFR Knockout HeLa Cell Lysate
NBP2-65185
Species: Hu
Applications: WB
EGFR Overexpression Lysate
EGFR Overexpression Lysate
NBP2-04608
Species: Hu
Applications: WB
Proteins
Recombinant Human EGFR Fc Chi ...
Recombinant Human EGFR Fc Chimera ...
344-ER
Species: Hu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Recombinant Human EGFR Protei ...
Recombinant Human EGFR Protein
1095-ER
Species: Hu
Applications: Bioactivity
Recombinant Mouse EGFR Fc Chi ...
Recombinant Mouse EGFR Fc Chimera ...
1280-ER
Species: Mu
Applications: Binding Activity
Formulation Catalog # Availability Price  

Description

Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation (1). Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor (2). The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding (3). Once activated, EGFR phosphotyrosines Y-1068 and Y-1173 mediate the binding of Grb2 to the EGFR. Addtionally, phosphotyrosine Y-1173 is a major binding site for SHC on the EGFR (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 1956
Alternate Names
  • ErbB1
  • HER1
  • EC 2.7.10
  • ERBB
  • mENA
  • epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog)
  • cell proliferation-inducing protein 61
  • EC 2.7.10.1
  • cell growth inhibiting protein 40
  • Receptor tyrosine-protein kinase erbB-1
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
  • Proto-oncogene c-ErbB-1
  • ERBB1PIG61
  • epidermal growth factor receptor

Research Areas for EGFR

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Growth and Development
Hypoxia
Phospho-Specific
Signal Transduction
Tumor Suppressors
Tyrosine Kinases

Bioinformatics Tool for EGFR

Discover related pathways, diseases and genes to EGFR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related EGFR Blog Posts

Check out the latest blog posts on EGFR.
Dual applications of a c-Myc antibody in mitochondrial research
c-Myc, a proto-oncogene, has documented involvement in cellular differentiation, cell growth, cell death and tumor formation.  Target genes of the Myc family include those that participate in cell survival, translation, transcription, metabolism and...    Read more.
The dynamic use of a PCNA antibody in fish, porcine and primate species
Proliferating cell nuclear antigen (PCNA) plays a crucial role in nucleic acid metabolism as it pertains to DNA replication and repair.  Most noted for its activation of subunits of DNA polymerase, it has also been found to interact with cell-cycl...    Read more.
Using a STAT3 antibody in chromatin immunoprecipitation (ChIP)
Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.
Beta Tubulin III and neurogenesis
Beta tubulin III, also known as Tuj-1, is a class III member of the beta tubulin protein family. Beta tubulins are one of two structural components that form our microtubule network. While general tubulins play a role in a wide range of cellular pr...    Read more.
The relationship between Ki67 and HIF-1 in cancer
Ki67, also known as MKI67, is best known as the leading marker of cellular proliferation. Ki67 is regulated by a balance between synthesis and degradation, and often carries a very short half-life.  First discovered to be located to dividing cells,...    Read more.
Niemann Pick-C1 and cholesterol dynamics
Niemann-Pick type C1 (NPC1) mediates low-density cholesterol transport from late endosomes and lysosomes to other areas of the cell via receptor mediation endocytosis.  Although cholesterol moves freely inside the cell, it cannot independently expo...    Read more.
MAPK3/ERK1 - A signal transduction pathway with roles in development and disease
Mitogen-activated protein kinases (MAPKs) are important signaling proteins needed to transmit and relay extracellular stimuli and to illicit intracellular responses (1). The MAPK family of proteins are serine/threonine kinases that are able to phos...    Read more.
Using EGF Protein from Novus Biologicals
EGF (epidermal growth factor) stimulates differentiation, proliferation and cell growth by binding to its receptor, EGFR. EGF was first discovered in the mouse submandibular gland in 1986 by Stanley Cohen of Vanderbilt University, leading to a Nobel P...    Read more.
It's a Wiz: Merlin Antibodies Advance Hepatic Tumor Research
The NF2 gene, also known as “Merlin”, was discovered through studies into Neurofibromatosis Type II, a rare genetic disease which causes formation of non-malignant, but life-limiting, brain tumors. NF2 encodes a cytoskeletal protein involved in extrac...    Read more.
The Magic of Merlin: Antibodies Point to New Role in Liver Cancer
The Merlin protein belongs to the ezrin/radixin/moesin (ERM) family of tumour suppressor proteins. Encoded by the rather less imaginatively named Neurofibromin 2 (NF2) gene, it is thought to play a role in extracellular signal transduction, linking th...    Read more.
Read more EGFR related blogs.