ECSIT Products

Antibodies
ECSIT Antibody
ECSIT Antibody
NBP1-76594
Species: Hu, Mu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
ECSIT Antibody
ECSIT Antibody
NBP1-77838
Species: Hu, Mu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
ECSIT Antibody (1B8)
ECSIT Antibody (1B8)
H00051295-M01
Species: Hu
Applications: ELISA, PLA
Host: Mouse Monoclonal
Proteins
ECSIT Recombinant Protein Ant ...
ECSIT Recombinant Protein Antigen
NBP1-91858PEP
Species: Hu
Applications: AC
Recombinant Human ECSIT Prote ...
Recombinant Human ECSIT Protein
NBP2-23017
Species: Hu
Applications: PAGE
ECSIT Peptide
ECSIT Peptide
NBP1-76594PEP
Species: Hu
Applications: AC
RNAi
ECSIT RNAi
ECSIT RNAi
H00051295-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 51295
Alternate Names
  • likely ortholog of mouse signaling intermediate in Toll pathway evolutionarilyconserved
  • Protein SITPEC
  • evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
  • SITPECsignaling intermediate in Toll pathway, evolutionarily conserved
  • signaling intermediate in Toll pathway evolutionarily conserved ortholog
  • ECSIT homolog (Drosophila)

Research Areas for ECSIT

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Signal Transduction
Wnt Signaling Pathway

PTMs for ECSIT

Learn more about PTMs related to ECSIT.

Phosphorylation
Cleavage
Oxidation
Methylation
Ubiquitination

Bioinformatics Tool for ECSIT

Discover related pathways, diseases and genes to ECSIT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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