Dystroglycan Products

Antibodies
Dystroglycan Antibody
Dystroglycan Antibody
AF6868
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Dystroglycan Antibody
Dystroglycan Antibody
NBP1-59781
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Dystroglycan [p Tyr893] Antib ...
Dystroglycan [p Tyr893] Antibody (...
NB100-78388
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Monoclonal
Lysates
Dystroglycan Overexpression L ...
Dystroglycan Overexpression Lysate...
NBL1-09713
Applications: WB

Description

Dystroglycan (also known as dystrophin-associated glycoprotein 1) is a member of the dystroglycan family that contains the WWW binding motif PPxY. This protein has alpha and beta subunits with approximate molecular weights of 156 kD and 43-50 kD, respectively. The dystroglycan beta subunit is an integral membrane protein, the alpha subunit is a ubiquitously expressed extracellular protein. Muscle and non-muscle isoforms differ by carbohydrate moieties (not protein sequence). Dystroglycan functions as an adhesion molecule responsible for interactions between extracellular matrix and the subsarcolemmal cytoskeleton. Dsytroglycan binds to lamin in the matrix and dystrophin in the cytoskeleton; phosphorylation regulates the association of interacting proteins. Dystroglycan binds to utrophin when unphosphorylated; c-Src, Fyn, Csk, NCK, and SHC when phosphorylated. Dystroglycan interacts with dystrophin through the WW domain. The Poly6171 antibody recognizes human phosphorylated dystroglycan (Tyr893) and has been shown to be useful for Western blotting.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 1605
Alternate Names
  • AGRNR
  • Dystrophin-associated glycoprotein 1
  • A3a
  • dystroglycan
  • DAG156DAG
  • dystroglycan 1 (dystrophin-associated glycoprotein 1)

Research Areas for Dystroglycan

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Phospho-Specific

PTMs for Dystroglycan

Learn more about PTMs related to Dystroglycan.

Glycosylation
Cleavage
Phosphorylation
Reduction
Biotinylation
Acetylation
Methylation

Bioinformatics Tool for Dystroglycan

Discover related pathways, diseases and genes to Dystroglycan. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Dystroglycan Blog Posts

Check out the latest blog posts on Dystroglycan.
Could Laminin be Used to Treat Duchenne Muscular Dystrophy?
Duchenne muscular dystrophy (DMD) is a severe muscle wasting condition, causing disability and early death. There is currently no cure or adequate treatment for DMD, but pioneering research indicates that injection of a laminin protein may prevent (or...    Read more.
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