DUOX1 Products

Description

The DUOX1 gene encodes a glycoprotein dual oxidase 1 protein with an isoform 1 of 1,551 amino acids long at 177 kDA and an isoform 2 at 1,197 amino acids long at 137 kDA. This protein is called a dual oxidase because it obtains a peroxidase homology domain and a gp91phox domain. DUOX1 generates hydrogen peroxide which is essential for thyroid peroxidase/TPO and lactoperoxidase/LPO, as well as lactoperoxidase-mediated antimicrobial defense. DUOX1 interacts with genes TXNDC11 and TPO and has been investigated for its role in various diseases such as thyroiditis, lung cancer, alcoholism, carcinoma, chronic obstructive pulmonary disease, hypothyroidism, hepatitis, prostatitis, and chronic granulomatous disease.

Bioinformatics

Product By Gene ID	53905
Alternate Names	dual oxidase 1 DUOX EC 1.11.1.- EC 1.6.3.1 Large NOX 1 LNOX1flavoprotein NADPH oxidase Long NOX 1 MGC138840 NADPH thyroid oxidase 1 nicotinamide adenine dinucleotide phosphate oxidase NOXEF1 THOX1MGC138841 Thyroid oxidase 1