Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, KO
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, Func
Host: Mouse Monoclonal
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA, also known as DNA fragmentation factor subunit alpha, is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Recombinant DFFA protein was expressed in E.coli and purified by using conventional chromatography techniques.
Bioinformatics
| Product By Gene ID |
1676 |
| Alternate Names |
- DFF1
- DFF1DNA fragmentation factor 45 kDa subunit
- DFF45
- DFF45DNA fragmentation factor subunit alpha
- DFF-45DNA fragmentation factor, 45 kD, alpha polypeptide
- DFFA
- DNA fragmentation factor, 45kDa, alpha polypeptide
- ICAD
- Inhibitor of CAD
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