DFF45/ICAD Products

Antibodies
DFF45/ICAD Antibody
DFF45/ICAD Antibody
NBP1-77034
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
DFF45/ICAD Antibody
DFF45/ICAD Antibody
NBP1-85248
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
DFF45/ICAD Antibody
DFF45/ICAD Antibody
AF4679
Species: Hu
Applications: WB
Host: Goat Polyclonal
Antibody Pairs
DFF45/ICAD Antibody Pair
DFF45/ICAD Antibody Pair
H00001676-AP11
Species: Hu
Applications: S-ELISA
DFF45/ICAD Antibody Pair
DFF45/ICAD Antibody Pair
H00001676-AP21
Species: Hu
Applications: S-ELISA
Lysates
DFF45/ICAD Overexpression Lys ...
DFF45/ICAD Overexpression Lysate (...
H00001676-T01
Species: Hu
Applications: WB
DFF45/ICAD Overexpression Lys ...
DFF45/ICAD Overexpression Lysate (...
NBL1-09842
Applications: WB
Proteins
Recombinant Human DFF45/ICAD ...
Recombinant Human DFF45/ICAD Protein
H00001676-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human DFF45/ICAD ...
Recombinant Human DFF45/ICAD Protein
H00001676-Q01
Species: Hu
Applications: WB, ELISA, PA
DFF45/ICAD Recombinant Protei ...
DFF45/ICAD Recombinant Protein Ant...
NBP1-85248PEP
Species: Hu
Applications: AC

Description

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 1676
Alternate Names
  • ICAD
  • DFF45DNA fragmentation factor subunit alpha
  • DFF-45DNA fragmentation factor, 45 kD, alpha polypeptide
  • DFF1DNA fragmentation factor 45 kDa subunit
  • Inhibitor of CAD
  • DNA fragmentation factor, 45kDa, alpha polypeptide

Research Areas for DFF45/ICAD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication
Tumor Suppressors

PTMs for DFF45/ICAD

Learn more about PTMs related to DFF45/ICAD.

Cleavage
Oxidation
Phosphorylation
Methylation

Bioinformatics Tool for DFF45/ICAD

Discover related pathways, diseases and genes to DFF45/ICAD. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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