Species: Hu, Mu, Rt, Ca, ChHa, Bv, Ch, Xp, Ze
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Derlin 1 (degradation in endoplasmic reticulum protein 1) belongs to Derlin family and is a functional sub-unit of the ER-associated degradation (ERAD), a ubiquitin/proteasome dependent degradation process for proteins which fails to fold correctly or assemble into oligomeric complexes in ER. Derlin 1 forms a channel which permits the retrotranslocation of misfolded proteins into cytosol from ER wherein they undergo ubiquitination mediated proteasomal degradation. Derlin 1 can generate homo-/hetero-oligomers with DERL2 and DERL3, and interacts with several other proteins such as AMFR, VIMP/SELS, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-VIMP protein complexes. It also interacts with cytomegalovirus US11 protein, NGLY1 and YOD1, RNF103 etc. Expressed ubiquitously, it can get up-regulated in response to ER stress via ERN1-XBP1 pathway of the UPR/unfolded protein response.
Bioinformatics
| Product By Gene ID |
79139 |
| Alternate Names |
- DER-1
- DER1Degradation in endoplasmic reticulum protein 1
- Der1-like domain family, member 1
- Der1-like protein 1
- derlin-1
- DERtrin-1
- FLJ13784
- FLJ42092
- MGC3067
- PRO2577
|
