DEC2/SHARP1 Products

Description

Human DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy, and Enhancer of split m7. DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells. DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1. DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes. Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion. Brief light impulses induce the expression of DEC1 in a phase-dependent manner.

Bioinformatics

Entrez	117095 Rat 79362 Mouse 79365 Human
Uniprot	NP_110389 Human Q9C0J9 Human
Product By Gene ID	79365
Alternate Names	basic helix-loop-helix domain containing, class B, 3 basic helix-loop-helix family, member e41 bHLHb3 BHLHB3class E basic helix-loop-helix protein 41 bHLHe41 Class B basic helix-loop-helix protein 3 DEC2Enhancer-of-split and hairy-related protein 1 Differentially expressed in chondrocytes protein 2 SHARP-1 SHARP1hDEC2

Related DEC2/SHARP1 Blog Posts

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SHARP1 - An enhancer-of-split- and hairy-related protein SHARP1 encodes a transcription repressor factor that belongs to the Hairy/Enhancer of the Split subfamily of basic helix-loop-helix factors (bHLH). Sequence alignment shows that SHARP1 is only distantly related to these proteins with a 37-42% sequence...    Read more.

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