Cystatin E/M/CST6 Products

Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Bioinformatics

Entrez	1474 Human
Uniprot	AAH31334 Human NM_001323 Human NP_001314 Human NP_001314.1 Human NP_082899 Mouse Q15828 Human
Product By Gene ID	1474
Alternate Names	cystatin 6 cystatin E/M cystatin M cystatin M/E cystatin-6 Cystatin-6 cystatin-E Cystatin-E cystatin-M cysteine proteinase inhibitor

Research Areas for Cystatin E/M/CST6

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Cancer