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HAF017). Specific bands were detected for COMP/Thrombospondin-5 at approximately 90 and 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
3134-CP), immobilized onto a microplate, supports the adhesion of the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Adhesion elicited by Recombinant Human COMP/Thrombospondin-5 (10 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human COMP/Thrombo-spondin-5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3134). The ND50 is typically 1-4 µg/mL." class="big_lightbox" target="_blank">
COMP is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED)
![Western Blot COMP/Thrombospondin-5 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/COMP_AF3134_Western_Blot_17834.jpg)
![Sandwich ELISA COMP/Thrombospondin-5 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/COMP-Thrombospondin-5-Antibody-Pair-[Biotin]-Sandwich-ELISA-NBP2-79472-img0001.jpg)
![N/A COMP/Thrombospondin-5 [HRP]](http://images.novusbio.com/fullsize/elisa/DATA_COMP_DCMP0_ELISA_632.jpg)
![N/A COMP/Thrombospondin-5 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_COMP_DY3134_ELISA_1918.jpg)
![Binding Activity COMP/Thrombospondin-5 [Unconjugated]](http://images.novusbio.com/fullsize/protein/COMP_8958CP_1066.jpg)
![Neutralization COMP/Thrombospondin-5 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/COMP_AF3134_Block_Neutralize_8842.jpg)
![N/A COMP/Thrombospondin-5 [HRP]](http://images.novusbio.com/fullsize/elisa/COMP_DCMP0_ELISA_66.jpg)
