COBRA1 Products

Description

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM]

Bioinformatics

Entrez	25920 Human
Uniprot	AAH11892 Human AAH11892.1 Human NP_056271.2 Human Q8WX92 Human
Product By Gene ID	25920
Alternate Names	cofactor of BRCA1DKFZp586B0519 KIAA1182negative elongation factor B NELFB NELF-Bnegative elongation factor protein B

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COBRA1: A Key Player in Transcriptional Pausing Co-factor of BRCA1, also known as COBRA1, was first identified as a protein that binds to the tumour suppressor protein encoded by the breast cancer susceptibility gene BRCA1 (1). It was subsequently found to be identical to subunit B of the Negative ...    Read more.

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