Coagulation Factor VII Products

Description

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq]

Bioinformatics

Product By Gene ID	2155
Alternate Names	coagulation factor VII (serum prothrombin conversion accelerator) Coagulation Factor VII EC 3.4.21 EC 3.4.21.21 Eptacog alfa F7 FVII coagulation protein proconvertin Serum prothrombin conversion accelerator SPCA