Home » Chk1 Products

We're moving to rndsystems.com. Come with us!

After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.

Register on R&D Systems

Chk1 Products

Antibodies
Chk1 Antibody - BSA Free
Chk1 Antibody - BSA Free
NB100-464
Western Blot Chk1 Antibody - BSA Free
Immunohistochemistry-Paraffin Chk1 Antibody - BSA Free
Western Blot Chk1 Antibody - BSA Free
Immunoprecipitation Chk1 Antibody - BSA Free
Western Blot Chk1 Antibody - BSA Free
Western Blot Chk1 Antibody - BSA Free
Species: Hu, Mu
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 NB100-464AF350
Alexa Fluor 405 NB100-464AF405
Alexa Fluor 488 NB100-464AF488
Alexa Fluor 532 NB100-464AF532
Alexa Fluor 594 NB100-464AF594
Alexa Fluor 647 NB100-464AF647
Alexa Fluor 700 NB100-464AF700
Alexa Fluor 750 NB100-464AF750
Alexa Fluor Plus 405 NB100-464AFP405
Alexa Fluor Plus 488 NB100-464AFP488
Alexa Fluor Plus 555 NB100-464AFP555
Alexa Fluor Plus 594 NB100-464AFP594
Alexa Fluor Plus 647 NB100-464AFP647
Alexa Fluor Plus 680 NB100-464AFP680
Allophycocyanin NB100-464APC
Biotin NB100-464B
CoraFluor 1 NB100-464CL1
DyLight 350 NB100-464UV
DyLight 405 NB100-464V
DyLight 488 NB100-464G
DyLight 550 NB100-464R
DyLight 594 NB100-464DL594
DyLight 650 NB100-464C
DyLight 680 NB100-464FR
DyLight 755 NB100-464IR
FITC NB100-464F
HRP NB100-464H
Janelia Fluor 525 NB100-464JF525
Janelia Fluor 549 NB100-464JF549
Janelia Fluor 646 NB100-464JF646
Janelia Fluor 669 NB100-464JF669
PE NB100-464PE
PerCP NB100-464PCP
mFluor Violet 450 SE NB100-464MFV450
mFluor Violet 500 SE NB100-464MFV500
mFluor Violet 610 SE NB100-464MFV610
Chk1 [p Ser317] Antibody [Unc ...
Chk1 [p Ser317] Antibody [Unconjug...
AF2054
HAF008). A specific band for Phospho-Chk1 (S317) was detected at approximately 56 kDa (as indicated). The phospho-specificity of this antibody was supported by decreased labeling following treatment with 600 U lambda-phosphatase (lambda-PPase) for 1 hour. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank"> Western Blot Chk1 [p Ser317] Antibody [Unconjugated]
Simple Western Chk1 [p Ser317] Antibody [Unconjugated]
Western Blot Chk1 [p Ser317] Antibody [Unconjugated]
Western Blot Chk1 [p Ser317] Antibody [Unconjugated]
Western Blot Chk1 [p Ser317] Antibody [Unconjugated]
Western Blot Chk1 [p Ser317] Antibody [Unconjugated]
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 AF2054U-100UG
Alexa Fluor 405 AF2054V-100UG
Alexa Fluor 488 AF2054G-100UG
Alexa Fluor 532 AF2054X-100UG
Alexa Fluor 594 AF2054T-100UG
Alexa Fluor 647 AF2054R-100UG
Alexa Fluor 700 AF2054N-100UG
Alexa Fluor 750 AF2054S-100UG
Alexa Fluor Plus 405 AF2054AFP405-100UG
Alexa Fluor Plus 488 AF2054AFP488-100UG
Alexa Fluor Plus 555 AF2054AFP555-100UG
Alexa Fluor Plus 594 AF2054AFP594-100UG
Alexa Fluor Plus 647 AF2054AFP647-100UG
Alexa Fluor Plus 680 AF2054AFP680-100UG
Allophycocyanin AF2054A
Biotin AF2054B
CoraFluor 1 AF2054CL1
DyLight 350 AF2054D
DyLight 405 AF2054E
DyLight 488 AF2054K
DyLight 550 AF2054L
DyLight 594 AF2054M
DyLight 650 AF2054W
DyLight 680 AF2054Y
DyLight 755 AF2054Z
FITC AF2054F
HRP AF2054H
Janelia Fluor 525 AF2054JF525
Janelia Fluor 549 AF2054I
Janelia Fluor 646 AF2054J
Janelia Fluor 669 AF2054JF669
PE AF2054P
PerCP AF2054C
mFluor Violet 450 SE AF2054MFV450
mFluor Violet 500 SE AF2054MFV500
mFluor Violet 610 SE AF2054MFV610
Formulation Catalog # Availability Price  
Carrier Free AF2054-SP
Chk1 Antibody (2G1D5) - BSA F ...
Chk1 Antibody (2G1D5) - BSA Free
NB100-1768
Western Blot Chk1 Antibody (2G1D5) - BSA Free
Immunocytochemistry/ Immunofluorescence Chk1 Antibody (2G1D5) - BSA Free
Immunohistochemistry-Paraffin Chk1 Antibody (2G1D5) - BSA Free
Western Blot Chk1 Antibody (2G1D5) - BSA Free
Species: Hu
Applications: WB, Simple Western, ICC/IF, IHC
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 NB100-1768AF350
Alexa Fluor 405 NB100-1768AF405
Alexa Fluor 488 NB100-1768AF488
Alexa Fluor 532 NB100-1768AF532
Alexa Fluor 594 NB100-1768AF594
Alexa Fluor 647 NB100-1768AF647
Alexa Fluor 700 NB100-1768AF700
Alexa Fluor 750 NB100-1768AF750
Alexa Fluor Plus 405 NB100-1768AFP405
Alexa Fluor Plus 488 NB100-1768AFP488
Alexa Fluor Plus 555 NB100-1768AFP555
Alexa Fluor Plus 594 NB100-1768AFP594
Alexa Fluor Plus 647 NB100-1768AFP647
Alexa Fluor Plus 680 NB100-1768AFP680
Allophycocyanin NB100-1768APC
Biotin NB100-1768B
CoraFluor 1 NB100-1768CL1
DyLight 350 NB100-1768UV
DyLight 405 NB100-1768V
DyLight 488 NB100-1768G
DyLight 550 NB100-1768R
DyLight 594 NB100-1768DL594
DyLight 650 NB100-1768C
DyLight 680 NB100-1768FR
DyLight 755 NB100-1768IR
FITC NB100-1768F
HRP NB100-1768H
Janelia Fluor 525 NB100-1768JF525
Janelia Fluor 549 NB100-1768JF549
Janelia Fluor 646 NB100-1768JF646
Janelia Fluor 669 NB100-1768JF669
PE NB100-1768PE
PerCP NB100-1768PCP
mFluor Violet 450 SE NB100-1768MFV450
mFluor Violet 500 SE NB100-1768MFV500
mFluor Violet 610 SE NB100-1768MFV610
Formulation Catalog # Availability Price  
BSA Free NB100-1768SS
Azide and BSA Free NBP2-80668
Read More
Read More
Read More
See All Chk1 Products
We have 36 Chk1 Antibodies
ELISA Kits
Mouse Chk1 - Ready-To-Use EL ...
Mouse Chk1 - Ready-To-Use ELISA K...
NBP3-54653
ELISA Mouse Chk1 - Ready-To-Use ELISA Kit (Colorimetric)
Species: Mu
Applications: ELISA
Mouse Chk1 ELISA Kit (Colorim ...
Mouse Chk1 ELISA Kit (Colorimetric)
NBP3-52669
ELISA Mouse Chk1 ELISA Kit (Colorimetric)
Species: Mu
Applications: ELISA
Read More
Read More
See All Chk1 Products
We have 2 Chk1 ELISA Kits
Lysates
Chk1 Overexpression Lysate
Chk1 Overexpression Lysate
NBL1-09146
Western Blot Chk1 Overexpression Lysate
Species: Hu
Applications: WB
Chk1 Overexpression Lysate
Chk1 Overexpression Lysate
NBP2-11408
Western Blot Chk1 Overexpression Lysate
Species: Hu
Applications: WB
Chk1 Overexpression Lysate
Chk1 Overexpression Lysate
NBP2-11409
Western Blot Chk1 Overexpression Lysate
Species: Hu
Applications: WB
Read More
Read More
Read More
See All Chk1 Products
We have 3 Chk1 Lysates
Proteins
Recombinant Human Active Chk1 ...
Recombinant Human Active Chk1 Prot...
1630-KS
SDS-Page Chk1 [Unconjugated]
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Carrier Free 1630-KS-010
Chk1 Recombinant Protein Anti ...
Chk1 Recombinant Protein Antigen
NBP2-58441PEP
Species: Hu
Applications: AC
Read More
Read More
See All Chk1 Products
We have 2 Chk1 Proteins

Description

Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).

Bioinformatics

Entrez
1111
Human
12649
Mouse
140583
Rat
Uniprot
AAH04202
Human
ABM87141.1
Human
NM_001274
Human
NP_001107593
Human
NP_001107594
Human
NP_001265
Human
O14757
Human
Product By Gene ID 1111
Alternate Names
  • Checkpoint, S. pombe, homolog of, 1
  • CHK1 (checkpoint, S.pombe) homolog
  • CHK1 checkpoint homolog (S. pombe)
  • CHK1serine/threonine-protein kinase Chk1
  • EC 2.7.11
  • EC 2.7.11.1

Research Areas for Chk1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific
Stem Cell Markers
Tumor Suppressors