Chk1 Products

Antibodies
Chk1 Antibody
Chk1 Antibody
Species: Hu, Po, Ca, Mk, Pm
Applications: WB, ICC/IF, IHC, IHC-P, PLA
Host: Rabbit Polyclonal
Chk1 Antibody (2G1D5)
Chk1 Antibody (2G1D5)
NB100-1768
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Chk1 [p Ser317] Antibody [Unc ...
Chk1 [p Ser317] Antibody [Unconjug...
AF2054
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Rabbit Polyclonal
Lysates
Chk1 Overexpression Lysate (N ...
Chk1 Overexpression Lysate (Native)
NBP2-11408
Applications: WB
Chk1 Overexpression Lysate (N ...
Chk1 Overexpression Lysate (Native)
NBP2-11409
Applications: WB
Chk1 Overexpression Lysate (N ...
Chk1 Overexpression Lysate (Native)
NBL1-09146
Applications: WB
Proteins
Recombinant Human Chk1 Protei ...
Recombinant Human Chk1 Protein
H00001111-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Chk1 Protei ...
Recombinant Human Chk1 Protein
H00001111-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Chk1 RNAi
Chk1 RNAi
H00001111-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 1111
Alternate Names
  • CHK1 (checkpoint, S.pombe) homolog
  • EC 2.7.11
  • EC 2.7.11.1
  • CHK1serine/threonine-protein kinase Chk1
  • Checkpoint, S. pombe, homolog of, 1
  • CHK1 checkpoint homolog (S. pombe)

Research Areas for Chk1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific
Stem Cell Markers
Tumor Suppressors

PTMs for Chk1

Learn more about PTMs related to Chk1.

Phosphorylation
Methylation
Acetylation

Bioinformatics Tool for Chk1

Discover related pathways, diseases and genes to Chk1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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