CHFR Products

Antibodies
CHFR Antibody (1H3-A12)
CHFR Antibody (1H3-A12)
H00055743-M01
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
CHFR Antibody
CHFR Antibody
NB100-1166
Species: Hu
Applications: IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
CHFR Antibody
CHFR Antibody
NBP1-52955
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
CHFR Overexpression Lysate (N ...
CHFR Overexpression Lysate (Native)
NBP2-10156
Applications: WB
Proteins
CHFR Recombinant Protein
CHFR Recombinant Protein
H00055743-P01
Species: Hu
Applications: WB, ELISA, PA
CHFR Partial Recombinant Prot ...
CHFR Partial Recombinant Protein
H00055743-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
CHFR RNAi
CHFR RNAi
H00055743-R01V
Species: Hu
Applications: WB, RNAi SP
CHFR RNAi
CHFR RNAi
H00055743-R01
Species: Hu

Description

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 55743
Alternate Names
  • RING finger protein 196
  • EC 6.3.2.-
  • Checkpoint with forkhead and RING finger domains protein
  • E3 ubiquitin-protein ligase CHFR
  • FLJ10796
  • RNF196RNF116
  • FLJ33629
  • checkpoint with forkhead and ring finger domains

Research Areas for CHFR

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Mitotic Regulators
Zinc Finger

Bioinformatics Tool for CHFR

Discover related pathways, diseases and genes to CHFR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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