CHFR Products

Description

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress

Bioinformatics

Entrez	231600 Mouse 288734 Rat 55743 Human
Uniprot	AAH12072 Human AAH12072.1 Human NP_001154816 Human NP_060693 Human NP_060693. Human Q96EP1 Human
Product By Gene ID	55743
Alternate Names	Checkpoint with forkhead and RING finger domains protein checkpoint with forkhead and ring finger domains E3 ubiquitin-protein ligase CHFR EC 6.3.2.- FLJ10796 FLJ33629 RING finger protein 196 RNF196RNF116

Research Areas for CHFR

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Mitotic Regulators
Zinc Finger