Species: Hu, Mu, Rt
Applications: WB, IP, KO
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: Simple Western, IHC
Host: Sheep Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Cdk8 is encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
1024 |
| Alternate Names |
- CDK8 protein kinase
- Cell division protein kinase 8
- cyclin-dependent kinase 8
- EC 2.7.11
- EC 2.7.11.22
- EC 2.7.11.23
- K35
- Mediator complex subunit CDK8
- Mediator of RNA polymerase II transcription subunit CDK8
- MGC126074
- MGC126075
- Protein kinase K35
|
Research Areas for CDK8
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and Replication
![Immunohistochemistry CDK8 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CDK8_AF6809_Immunohistochemistry_10938.jpg)
![Simple Western CDK8 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af6809_human-cdk8-affinity-purified-polyclonal-ab-simple-western-3072025142735..jpg)
