CDK8 Products

Description

Cdk8 is encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Bioinformatics

Product By Gene ID	1024
Alternate Names	CDK8 protein kinase CDK8 Cell division protein kinase 8 cyclin-dependent kinase 8 EC 2.7.11 EC 2.7.11.22 EC 2.7.11.23 K35 Mediator complex subunit CDK8 Mediator of RNA polymerase II transcription subunit CDK8 MGC126074 MGC126075 Protein kinase K35

Research Areas for CDK8

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

Related CDK8 Blog Posts

Check out the latest blog posts on CDK8.

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