CBFB Products

Description

The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, alpha and beta, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2alpha subunits, PEBP2alphaA, PEBP2alphaB and PEBP2alphaC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory beta subunit, which facilitates DNA binding of the alpha subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2beta is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2beta/CBFbeta-SMMHC, that is associated with human acute myeloid leukemia.

Bioinformatics

Entrez	12400 Mouse 361391 Rat 865 Human
Uniprot	AAH18509 Human NM_001755 Human NP_001746 Human NP_001746.1 Human NP_074036 Human NP_074036.1 Human Q13951 Human
Product By Gene ID	865
Alternate Names	CBF-beta core-binding factor subunit beta core-binding factor, beta subunit PEA2-beta PEBP2B PEBP2-beta polyomavirus enhancer binding protein 2, beta subunit Polyomavirus enhancer-binding protein 2 beta subunit SL3/AKV core-binding factor beta subunit SL3-3 enhancer factor 1 beta subunit SL3-3 enhancer factor 1 subunit beta