CBFB Products

Antibodies
CBFB Antibody
CBFB Antibody
AF7349
Species: Hu, Mu
Applications: WB, ICC
Host: Sheep Polyclonal
CBFB Antibody
CBFB Antibody
NBP1-87300
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CBFB Antibody
CBFB Antibody
H00000865-B01P
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Lysates
CBFB Overexpression Lysate (N ...
CBFB Overexpression Lysate (Native)
NBP2-06393
Applications: WB
CBFB Overexpression Lysate (N ...
CBFB Overexpression Lysate (Native)
NBL1-08735
Applications: WB
CBFB Overexpression Lysate (D ...
CBFB Overexpression Lysate (Denatu...
H00000865-T01
Species: Hu
Applications: WB
Proteins
CBFB Recombinant Protein Anti ...
CBFB Recombinant Protein Antigen
NBP1-87300PEP
Species: Hu
Applications: AC
Recombinant Human CBFB Protei ...
Recombinant Human CBFB Protein
NBP1-45317
Species: Hu
Applications: PAGE
RNAi
CBFB RNAi
CBFB RNAi
H00000865-R02
Species: Hu
Applications: RNAi, RNAi SP
CBFB RNAi
CBFB RNAi
H00000865-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, alpha and beta, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2alpha subunits, PEBP2alphaA, PEBP2alphaB and PEBP2alphaC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory beta subunit, which facilitates DNA binding of the alpha subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2beta is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2beta/CBFbeta-SMMHC, that is associated with human acute myeloid leukemia.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 865
Alternate Names
  • PEBP2-beta
  • SL3-3 enhancer factor 1 beta subunit
  • PEA2-beta
  • polyomavirus enhancer binding protein 2, beta subunit
  • CBF-beta
  • core-binding factor subunit beta
  • Polyomavirus enhancer-binding protein 2 beta subunit
  • SL3/AKV core-binding factor beta subunit
  • PEBP2B
  • SL3-3 enhancer factor 1 subunit beta
  • core-binding factor, beta subunit

PTMs for CBFB

Learn more about PTMs related to CBFB.

Methylation
Phosphorylation
Biotinylation
Cleavage
Acetylation

Bioinformatics Tool for CBFB

Discover related pathways, diseases and genes to CBFB. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.