Caspase-4 Products

Description

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]. Transcript Variant: This variant (gamma) includes an alternate exon in the 5' UTR and 5' coding region and uses a downstream in-frame start codon, compared to variant alpha. It encodes isoform gamma, which is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	837
Alternate Names	apoptotic cysteine protease Mih1/TX CASP4 CASP-4 caspase 4, apoptosis-related cysteine peptidase caspase 4, apoptosis-related cysteine protease Caspase4 Caspase-4 EC 3.4.22 EC 3.4.22.57 ICE(rel)II ICE(rel)-II ICEREL-II ICH2 ICH-2 Mih1/TX Protease ICH-2 Protease TX TX

Research Areas for Caspase-4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

Related Caspase-4 Blog Posts

Check out the latest blog posts on Caspase-4.

The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver By Victoria Osinski, PhDWhat is the NLRP3 Inflammasome?With its critical role in innate immunity, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ...    Read more.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

Caspase-4 - a human protease with roles in inflammation and immunity Caspases are a family of cysteine-aspartic acid proteases that cleave caspase proenzymes as well as other protein substrates. Caspases are well known for their role in apoptosis, but they also play a significant role in other cellular processes inc...    Read more.

Read more Caspase-4 related blogs.