Carbohydrate Sulfotransferase 15/CHST15 Products

Description

GALNAC4S-6ST is a sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. GALNAC4S-6ST may also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.

Bioinformatics

Uniprot	Q7LFX5
Product By Gene ID	51363
Alternate Names	B cell RAG associated protein (GALNAC4S-6ST) B-cell RAG-associated gene protein BRAG BRAGKIAA0598RP11-47G11.1 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 Carbohydrate Sulfotransferase 15 CHST15 DKFZp781H1369 EC 2.8.2.33 GALNAC4S6ST GalNAc4S-6ST hBRAG MGC34346 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase