Calpain 1 Products

Description

The calpain (calcium-dependent protease or calcium-activated neutral protease) system consists of two ubiquitous forms of calpain (Mu Calpain and M Calpain), a tissue specific calpain (N Calpain), and a calpain inhibitory protein (calpastatin). The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death.Mu and M Calpains are heterodimers consisting of 28 kDa and 80 kDa subunits. The 28 kDa subunit is identical in the two isoforms, but the 80 kDa subunits differ with ~50% sequence similarity. 28 kDa / 80 kDa complexes are thought to be inactive proenzymes which, upon binding of calcium, undergo conformational changes that promotes cleavage of the 28 kDa subunit and results in enzyme activation.

Bioinformatics

Entrez	12333 Mouse 281661 Bovine 29153 Rat 823 Human
Uniprot	AAH08751 Human NM_005186 Human NP_005177 Human NP_005177.2 Human P07384 Human Q27970 Bovine
Product By Gene ID	823
Alternate Names	Calcium-activated neutral proteinase 1 calpain 1, (mu/I) large subunit Calpain mu-type calpain, large polypeptide L1 calpain-1 catalytic subunit Calpain-1 large subunit CANP 1 CANP CANPL1EC 3.4.22.52 Cell proliferation-inducing gene 30 protein cell proliferation-inducing protein 30 EC 3.4.22 Micromolar-calpain micromolar-calpain muCANPCANP1 muCL

Research Areas for Calpain 1

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Cell Cycle and Replication