Calpain 1 Products

Antibodies
Calpain 1 Antibody (107-82)
Calpain 1 Antibody (107-82)
NB120-3588
Species: Hu, Mu, Rt, Po, Rb
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr
Host: Mouse Monoclonal
Calpain 1 Antibody
Calpain 1 Antibody
NBP2-15671
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Antibody Pairs
Calpain 1 Antibody Pair
Calpain 1 Antibody Pair
H00000823-PW1
Species: Hu
Applications: WB, IP
Kits
Calpain 1 Assay Kit
Calpain 1 Assay Kit
KA0723
Species: Ma
Applications: Func
Lysates
Calpain 1 Overexpression Lysa ...
Calpain 1 Overexpression Lysate (D...
H00000823-T01
Species: Hu
Applications: WB
Calpain 1 Overexpression Lysa ...
Calpain 1 Overexpression Lysate (N...
NBL1-08677
Applications: WB
Proteins
Calpain 1 Recombinant Protein ...
Calpain 1 Recombinant Protein Antigen
NBP1-88205PEP
Species: Hu
Applications: AC
Calpain 1 Human Expressed Pro ...
Calpain 1 Human Expressed Protein
P4041
Species: Hu
Applications: Func, PAGE
Calpain 1 Biologically Active ...
Calpain 1 Biologically Active Protein
NBP1-99920
Species: Hu
RNAi
Calpain 1 RNAi
Calpain 1 RNAi
H00000823-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The calpain (calcium-dependent protease or calcium-activated neutral protease) system consists of two ubiquitous forms of calpain (Mu Calpain and M Calpain), a tissue specific calpain (N Calpain), and a calpain inhibitory protein (calpastatin). The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death.Mu and M Calpains are heterodimers consisting of 28 kDa and 80 kDa subunits. The 28 kDa subunit is identical in the two isoforms, but the 80 kDa subunits differ with ~50% sequence similarity. 28 kDa / 80 kDa complexes are thought to be inactive proenzymes which, upon binding of calcium, undergo conformational changes that promotes cleavage of the 28 kDa subunit and results in enzyme activation.

Bioinformatics

Entrez Human
Mouse
Rat
Bovine
Uniprot Human
Human
Human
Human
Human
Bovine
Product By Gene ID 823
Alternate Names
  • EC 3.4.22
  • Cell proliferation-inducing gene 30 protein
  • Micromolar-calpain
  • Calpain-1 large subunit
  • micromolar-calpain
  • Calpain mu-type
  • cell proliferation-inducing protein 30
  • Calcium-activated neutral proteinase 1
  • calpain-1 catalytic subunit
  • muCL
  • calpain, large polypeptide L1
  • CANP
  • muCANPCANP1
  • CANPL1EC 3.4.22.52
  • CANP 1
  • calpain 1, (mu/I) large subunit

Research Areas for Calpain 1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

PTMs for Calpain 1

Learn more about PTMs related to Calpain 1.

Cleavage
Phosphorylation
Oxidation
Acetylation
Dephosphorylation
Ribosylation
Ubiquitination

Bioinformatics Tool for Calpain 1

Discover related pathways, diseases and genes to Calpain 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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