BRIP1/FANCJ Products

Description

FANCJ (Fanconi anemia group J protein) was originally identified as a protein which binds BRCT domains of BRCA1 and was named BACH1 (BRCA1-Associated C-terminal Helicase1) or BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1), and after its identification as a component of Fanconi anemia pathway, it was renamed as FANCJ. It is expressed ubiquitously with highest levels in testes and sub-cellularly, it localizes to the nucleus. FANCJ is a DNA-dependent ATPase with 5' to 3' DNA helicase activity which is essential for genetic and structural integrity of genome. FANCJ acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination, and is implicated in repairing DNA double-strand breaks through homologous recombination in FANCJ-BRCA1 interactions dependent manner. Cell-cycle regulated phosphorylation of FANCJ is essential for BRCA1 interaction and 4Fe-4S iron-sulfur-binding is required for its helicase activity. The interaction of FANCJ with proteins including MutLalpha complex and BRCA1, suggests its importance in other pathways of DNA repair and in diseases such as colon and breast cancer. Defective FANCJ causes chromosome instability disorder Fanconi anemia complementation group J.

Bioinformatics

Entrez	83990 Human
Uniprot	Q9BX63
Product By Gene ID	83990
Alternate Names	ATP-dependent RNA helicase BRIP1 BACH1 BACH1BRCA1/BRCA2-associated helicase 1 BRCA1 interacting protein C-terminal helicase 1 BRCA1-associated C-terminal helicase 1 BRCA1-binding helicase-like protein BACH1 BRCA1-interacting protein 1 BRCA1-interacting protein C-terminal helicase 1 BRIP1 EC 3.6.1 EC 3.6.4.13 FACJ FANCJ FANCJFanconi anemia group J protein FLJ90232 MGC126521 MGC126523 OF Protein FACJ

Research Areas for BRIP1/FANCJ

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Chromatin Research
DNA Double Strand Break Repair
DNA Repair
Genes Sensitive to DNA Damaging Agents