Species: Hu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Bioinformatics
| Product By Gene ID |
663 |
| Alternate Names |
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
- BCL2/adenovirus E1B 19kDa interacting protein 2
- BCL2/adenovirus E1B 19kD-interacting protein 2
- BNIP-2
- NIP2
|
Research Areas for BNIP2
Find related products by research area and learn more about each of the different research areas below.
Apoptosis
