BMI-1 Products

Description

Bmi1 polycomb ring finger oncogene regulates the cell cycle inhibitor genes p16 and p19, with implications in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Bmi 1 has been shown to induce telomerase activity and immortalize human mammary epithelial cells, and extend the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi-1 is also required for efficient self-renewing cell division in adult hematopoietic and neural stem cells.

Aberrant expression of Bmi-1 has been found in several types of cancer in the bladder, skin, blood, prostate, breast, ovaries, andcolon. Its overexpression is especially pronounced in mantle cell lymphomas. Thereforem Bmi1 antibodies will be useful tools for many cancer development studies.

Bioinformatics

Product By Gene ID	648
Alternate Names	B lymphoma Mo-MLV insertion region 1 homolog (mouse) B lymphoma Mo-MLV insertion region 1 homolog BMI1 polycomb ring finger oncogene BMI1 BMI-1 FLVI2/BMI1 MGC12685 murine leukemia viral (bmi-1) oncogene homolog PCGF4 polycomb complex protein BMI-1 polycomb group protein Bmi1 polycomb group ring finger 4 RING finger protein 51 RNF51 RNF51Polycomb group RING finger protein 4

Research Areas for BMI-1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cancer Stem Cells
Cell Biology
Cell Cycle and Replication
Chromatin Research
DNA Repair
DNA replication, Transcription, Translation and Splicing
Epigenetics
Hematopoietic Stem Cell Markers
Stem Cell Markers
Transcription Factors and Regulators