B4GALT4 Products

Description

B4GALT4 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.

Bioinformatics

Entrez	8702 Human
Uniprot	AAH04523.1 Human NM_003778 Human NP_003769 Human NP_997708 Human O60513 Human
Product By Gene ID	8702
Alternate Names	b4Gal-T4 B4Gal-T4 beta-1,4-galactosyltransferase 4 Beta-1,4-GalTase 4 Beta4Gal-T4 beta4Gal-T4 beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4 EC 2.4.1.- UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4