B-Raf Products

Description

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Bioinformatics

Entrez	673 Human
Uniprot	NP_004324 Human
Product By Gene ID	673
Alternate Names	94 kDa B-raf protein B-Raf proto-oncogene serine/threonine-protein kinase (p94) BRaf B-Raf BRAF1 B-RAF1 BRAF1MGC126806 EC 2.7.11.1 MGC138284 murine sarcoma viral (v-raf) oncogene homolog B1 NS7 p94 Proto-oncogene B-Raf RAFB1 serine/threonine-protein kinase B-raf v-raf murine sarcoma viral oncogene homolog B1FLJ95109

Research Areas for B-Raf

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

Related B-Raf Blog Posts

Check out the latest blog posts on B-Raf.

Autophagy and RAS signaling: Clinical implications By Christina Towers, PhD The cellular recycling process known as autophagy is currently being targeted in over 60 clinical trials focused on treating different types of cancer1. To date, the only autophagy-targeted ...    Read more.

MAPK3/ERK1 - A signal transduction pathway with roles in development and disease Mitogen-activated protein kinases (MAPKs) are important signaling proteins needed to transmit and relay extracellular stimuli and to illicit intracellular responses (1). The MAPK family of proteins are serine/threonine kinases that are able to phos...    Read more.

You can't be without me - SNF5 The protein encoded by SNF5 is a component of the chromatin-remodeling protein complex responsible for relieving repressive chromatin structures by allowing the transcriptional machinery to access targets more effectively. SNF5 has been found to be a ...    Read more.

Read more B-Raf related blogs.