Aurora C Products

Description

Aurora-C is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Studies show that human Aurora-C is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins. INCENP binds and activates Aurora-C in vivo and in vitro. Aurora-C co-expressed with INCENP elicits the phosphorylation of endogenous histone H3 in mammalian cells, even though this phosphorylation is not sufficient to establish chromosome condensation in interphase cells (2). Over-expression of an inactive mutant of Aurora C impaired the localization of Aurora C to the spindle midzone resulting in multinucleation which demonstrates that Aurora C is required for cytokinesis (3).

Bioinformatics

Entrez	6795 Human
Uniprot	NM_001015878 Human NM_003160 Human NP_001015878.1 Human NP_003151 Human Q9UQB9 Human
Product By Gene ID	6795
Alternate Names	AIE2AIK3 ARK3Serine/threonine-protein kinase aurora-C AurC aurora kinase CAurora/IPL1/Eg2 protein 2 Aurora/IPL1-related kinase 3 aurora-C Aurora-related kinase 3 EC 2.7.11 EC 2.7.11.1 serine/threonine kinase 13 (aurora/IPL1-like) serine/threonine-protein kinase 13 STK13ARK-3

Research Areas for Aurora C

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Cell Cycle and Replication