APP Products

Antibodies
ELISA Kits
Human APP ELISA Kit (Colorime ...
Human APP ELISA Kit (Colorimetric)
NBP2-61301
Species: Hu
Applications: ELISA
Human APP ELISA Kit (Chemilum ...
Human APP ELISA Kit (Chemiluminesc...
NBP2-66740
Species: Hu
Applications: ELISA
Rat APP ELISA Kit (Colorimetr ...
Rat APP ELISA Kit (Colorimetric)
NBP2-78747
Species: Rt
Applications: ELISA
Lysates
APP Overexpression Lysate
APP Overexpression Lysate
NBP2-04578
Species: Hu
Applications: WB
APP Overexpression Lysate
APP Overexpression Lysate
NBL1-07632
Species: Hu
Applications: WB
APP Overexpression Lysate
APP Overexpression Lysate
NBP2-09023
Species: Hu
Applications: WB
Proteins
Recombinant Human APP/Proteas ...
Recombinant Human APP/Protease Nex...
3466-PI
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
APP Recombinant Protein Antig ...
APP Recombinant Protein Antigen
NBP1-90246PEP
Species: Hu
Applications: AC
APP Blocking Peptide
APP Blocking Peptide
NBP1-76910PEP
Species: Hu
Applications: AC

Description

Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (A 4) protein has been found to be the principal constituent of senile plaques of AD's patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa A 4 protein. Two variants of A 4 can be detected; A 1-40 "short-tailed" and A 1-42 "long-tailed" (3-4).

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 351
Alternate Names
  • Amyloid beta precursor protein
  • APP
  • amyloid beta A4 precursor protein-binding family B member 2
  • amyloid beta (A4) precursor protein-binding, family B, member 2

Research Areas for APP

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Cell Cycle and Replication
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Phospho-Specific

Bioinformatics Tool for APP

Discover related pathways, diseases and genes to APP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related APP Blog Posts

Check out the latest blog posts on APP.
Mechanisms of Neurodegeneration: Protein aggregation and failure of autophagy
By Michalina Hanzel, PhDIn a series of three blog posts I will briefly explore the major cellular mechanisms responsible for many neurodegenerative disorders. The first, and perhaps the most apparent, is the accumulat...    Read more.

    Read more.
Lysosomal Dysfunction is Linked to Exosomal Secretion
By Christina Towers, PhD. Lysosomal Dysfunction and DiseaseLysosomes are highly acidic organelles that are critical for cellular function and indispensable for degradative pathways like autophagy and endocytosis....    Read more.
Immunity’s flipside: Microglia promote Alzheimer’s pathology during inflammation
By Jamshed Arslan Pharm.D. Microglia are brain's macrophages. In Alzheimer's disease (AD), microglia clear up protein aggregates called amyloid beta plaques. The connection between immune activation and AD is unclea...    Read more.
The C99 fragment of amyloid precursor protein (APP)
Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...    Read more.
Beta Amyloid (MOAB2) and the link between traumatic brain injury and Alzheimer’s disease
An epidemiological association between traumatic brain injury (TBI) and Alzheimer's disease (AD) has long been established.  Interestingly, an increase in beta amyloid  (one hallmark of AD) directly following TBI has been observed.  In fact, it h...    Read more.
Niemann Pick-C1 and cholesterol dynamics
Niemann-Pick type C1 (NPC1) mediates low-density cholesterol transport from late endosomes and lysosomes to other areas of the cell via receptor mediation endocytosis.  Although cholesterol moves freely inside the cell, it cannot independently expo...    Read more.
FANCD2 and DNA damage repair
Fanconi anemia (FA) is a genetically inherited disorder that yields cytogenetic instability, hypersensitivity to DNA crosslinking compounds and defective DNA repair. A variety of genes have been identified within the FA pathway that are referred t...    Read more.
Beta Amyloid Neurotoxicity and Alzheimer's Disease
A major histopathological hallmark of Alzheimer's disease (AD) is the presence of amyloid deposits in the parenchyma of the amygdala, hippocampus, and neocortex. The principal component of amyloid is beta amyloid (AB). The pathologic accumulation of A...    Read more.
ApoE: The Key to Preventing Alzheimer's Disease?
Apolipoprotein E also known as ApoE is a 36kDa protein that is expressed in all lipoprotein fractions in plasma. This protein is produced in high quantities in the liver, brain, spleen, lung and kidney. The function of APOE is to mediate the binding,...    Read more.
Amyloid beta and Methionine Sulfoxide Related to Abeta 42 Antibody and Abeta 40 Antibody
By Eric NeeleyAlzheimer's disease is a devastating neurodegenerative illness characterized by the formation of plaques, tangles, and eventually synaptic loss. Amyloid beta (A beta ) is the processed form of the Amyloid precursor protein (APP), and whose...    Read more.
Read more APP related blogs.