ALK/CD246 Products

Antibodies
ALK/CD246 Antibody
ALK/CD246 Antibody
AF4210
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
ALK/CD246 Antibody (383625)
ALK/CD246 Antibody (383625)
MAB4210
Species: Hu
Applications: WB
Host: Mouse Monoclonal
ALK/CD246 Antibody (SP8)
ALK/CD246 Antibody (SP8)
NB120-16670
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
Lysates
ALK/CD246 Overexpression Lysa ...
ALK/CD246 Overexpression Lysate (N...
NBP2-07883
Applications: WB
Proteins
ALK/CD246 Recombinant Protein ...
ALK/CD246 Recombinant Protein Antigen
NBP2-48518PEP
Species: Hu
Applications: AC
ALK/CD246 Recombinant Protein ...
ALK/CD246 Recombinant Protein
P4855
Species: Hu
Applications: PAGE
RNAi
ALK/CD246 RNAi
ALK/CD246 RNAi
H00000238-R04
Species: Hu

Description

ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23 (1). In the predicted hybrid protein, the amino terminus of NPM is linked to the catalytic domain of ALK. Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the neonatal brain (2). Also expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas (3).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 238
Alternate Names
  • Anaplastic lymphoma kinase
  • EC 2.7.10.1
  • ALK tyrosine kinase receptor
  • CD246 antigen
  • anaplastic lymphoma kinase (Ki-1)
  • CD246
  • NBLST3
  • anaplastic lymphoma receptor tyrosine kinase

Research Areas for ALK/CD246

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction

Bioinformatics Tool for ALK/CD246

Discover related pathways, diseases and genes to ALK/CD246. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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