AKR1C2 Products

Description

AKR1C2 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Bioinformatics

Entrez	1646 Human
Uniprot	AAH07024 Human AAH07024.1 Human AAH63574 Human NM_001354 Human NP_995317 Human P52895 Human
Product By Gene ID	1646
Alternate Names	aldo-keto reductase family 1 member C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acidbinding protein; 3-alpha hydroxysteroid dehydrogenase, type III) BABP Chlordecone reductase homolog HAKRD DD DD-2 DD2DD/BABP DDH2FLJ53800 Dihydrodiol dehydrogenase 2 Dihydrodiol dehydrogenase/bile acid-binding protein EC 1.1.1,3-alpha-HSD3 EC 1.1.1.213 EC 1.3.1.20 HAKRDAKR1C-pseudo HBAB MCDR2 pseudo-chlordecone reductase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase type II dihydrodiol dehydrogenase Type III 3-alpha-hydroxysteroid dehydrogenase

Diseases related to AKR1C2

Discover more about diseases related to AKR1C2.

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Breast
Carcinoma
Prostatic Neoplasms
Cholestasis
Liver Carcinoma
Mammary Neoplasms
Adenocarcinoma
Obesity
Malignant Tumor Of Colon
Carcinogenesis
Hypercholesterolemia
Ductal Breast Carcinoma
Lung Neoplasms
Malignant Neoplasm Of Lung
Hyperplasia
Endometriosis, Site Unspecified
Intrahepatic Cholestasis

Pathways for AKR1C2

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Transport
Secretion
Cell Proliferation
Localization
Excretion
Conjugation
Drug Resistance
Intracellular Transport
Parturition
Pathogenesis
Cholesterol Homeostasis
Intestinal Absorption
Cell Cycle
Anion Transport
Lipid Binding
Ovulation
Cell Death
Cell Adhesion
Glycosylation
Regeneration

PTMs for AKR1C2

Learn more about PTMs related to AKR1C2.

Phosphorylation
Reduction
Cleavage
Oxidation
Carboxylation
Hydroxylation
Glycosylation

Bioinformatics Tool for AKR1C2

Discover related pathways, diseases and genes to AKR1C2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.