ADAM22 Products

Antibodies
ADAM22 Antibody
ADAM22 Antibody
NBP2-15282
Species: Hu, Mu
Applications: WB, IHC, IHC-Fr
Host: Rabbit Polyclonal
ADAM22 Antibody (498805) [Unc ...
ADAM22 Antibody (498805) [Unconjug...
MAB49081
Species: Hu
Applications: WB, IP
Host: Mouse Monoclonal
ADAM22 Antibody
ADAM22 Antibody
AF4908
Species: Hu
Applications: WB, IP
Host: Sheep Polyclonal
Lysates
ADAM22 Overexpression Lysate ...
ADAM22 Overexpression Lysate (Dena...
H00053616-T01
Species: Hu
Applications: WB
Proteins
ADAM22 Recombinant Protein
ADAM22 Recombinant Protein
H00053616-P01
Species: Hu
Applications: WB, ELISA, PA

Description

ADAM22 was first described as MDC2 (Metalloproteinase-like disintergin like cysteine rich 2) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends have been described. ADAM22 participates in cell adhesion and spreading by associating with 14-3-3 proteins. It is constitutively produced in normal brain tissue, but decreased or absent in high grade gliomas. Different splice variants of ADAM22 are differentially expressed in areas of the brain. A complex of ADAM22 and LGI1 were shown to regulate synaptic transmission. Complexes of ADAM22, stargazing, and a range of other proteins anchor ADAM22 into the cytoskeleton, and keep ADAM22 in association with the postsynaptic space. ADAM22 does not contain the canonical HExxHxxxxxH zinc metalloproteinase motif, and is not thought to be proteolytically active. ADAM22 is a member of the ADAMS that function in tandem with other ADAMs and which may also have specific individual functions.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Mouse
Product By Gene ID 53616
Alternate Names
  • metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
  • ADAM 22
  • metalloproteinase-disintegrin ADAM22-3
  • MGC149832
  • ADAM metallopeptidase domain 22

PTMs for ADAM22

Learn more about PTMs related to ADAM22.

Phosphorylation
Palmitoylation

Bioinformatics Tool for ADAM22

Discover related pathways, diseases and genes to ADAM22. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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