ABCG5 Products

Description

The protein encoded by the ABCG5 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into sevendistinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily.The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliaryexcretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene istandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene maycontribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.(provided by RefSeq)

Bioinformatics

Entrez	64240 Human
Uniprot	NP_071881 Human Q9H222 Human
Product By Gene ID	64240
Alternate Names	Sterolin-1 ATP-binding cassette sub-family G member 5 sterolin-1 sterolin 1 STSL ATP-binding cassette, subfamily G, member 5 ATP-binding cassette, sub-family G (WHITE), member 5

Diseases related to ABCG5

Discover more about diseases related to ABCG5.

Sitosterolemia
Hypercholesterolemia
Atherosclerosis
Cholecystolithiasis
Cardiovascular Diseases
Insulin Resistance
Malignant Neoplasms
Inflammation
Hyperlipidemia
Xanthoma
Heart Diseases
Coronary Heart Disease
Diabetes Mellitus
Obesity
Dyslipidemias
Cholestasis
Arteriosclerosis
Coronary Artery Disease
Cholelithiasis

Pathways for ABCG5

View related products by pathway and learn more about each of the pathways below.

Transport
Secretion
Excretion
Cholesterol Transport
Intestinal Cholesterol Absorption
Cholesterol Homeostasis
Intestinal Absorption
Reverse Cholesterol Transport
Cholesterol Efflux
Gallstone Formation
Sterol Transport
Lipid Transport
Localization
Lipid Homeostasis
Pathogenesis
Regulation Of Intestinal Cholesterol Absorption
Cholesterol Esterification
Bile Acid Secretion
Acid Secretion
Sterol Homeostasis

PTMs for ABCG5

Learn more about PTMs related to ABCG5.

Phosphorylation
Oxidation
Cleavage
Glycosylation
Methylation
Reduction
Acetylation
Palmitoylation
Deglycosylation

Bioinformatics Tool for ABCG5

Discover related pathways, diseases and genes to ABCG5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related ABCG5 Blog Posts

Check out the latest blog posts on ABCG5.

ABCG8: Cholesterol's Fate The ATP-binding cassette (ABC) transporter genes are key gatekeeper molecules that regulate the amount of dietary cholesterol retained by the body. They are a multifamily comprised of cAMP-dependent anion transporter cell membrane proteins that monito...    Read more.

ABCG2: A Tumor Protector ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1). The ABC transporters...    Read more.

Exploring how ABCG8 Affects Heart Disease The high prevalence of atherosclerosis in developed nations is not breaking news; it has been well established that heart disease is the leading cause of death in the United States, and it presents a major socioeconomic burden. Investigators across th...    Read more.

Read more ABCG5 related blogs.