A20/TNFAIP3 Products

Antibodies
A20/TNFAIP3 Antibody (SN07-31 ...
A20/TNFAIP3 Antibody (SN07-31)
NBP2-67676
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
A20/TNFAIP3 Antibody
A20/TNFAIP3 Antibody
NBP1-77024
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, ICC/IF
Host: Rabbit Polyclonal
Lysates
A20/TNFAIP3 Overexpression Ly ...
A20/TNFAIP3 Overexpression Lysate
NBP2-07646
Species: Hu
Applications: WB
Proteins
Recombinant Human A20/TNFAIP3 ...
Recombinant Human A20/TNFAIP3 GST ...
H00007128-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human A20/TNFAIP3 ...
Recombinant Human A20/TNFAIP3 GST ...
H00007128-P01
Species: Hu
Applications: WB, ELISA, PA, AP
A20/TNFAIP3 Antibody Blocking ...
A20/TNFAIP3 Antibody Blocking Peptide
NBP1-77351PEP
Species: Hu
Applications: AC

Description

A20, TNFalpha-induced protein 3, TNFAIP3 (theoretical molecular weight 95 kDa) is an important regulator of pro-inflammatory signaling pathways such as NF-kB activation and tumor necrosis factor (TNF)-mediated programmed cell death (1, 2). In macrophages, A20/TNFAIP3 controls the release of IL-1 beta/IL-18 by regulating NLRP3 inflammasome activity and CXCL9/CXCL10 production via STAT1 signaling. By regulating the expression of inflammatory molecules such as IL-6 and anti-apoptotic proteins in dendritic cells, A20/TNFAIP3 maintains T-cell and B-cell homeostasis.

A20/TNFAIP3 is a highly conserved protein sharing >90% amino acid sequence identity across various mammalian species and is highly expressed in T-cell and B-cells. Coding and non-coding single nucleotide polymorphisms (SNPs) of A20/TNFAIP3 have been associated with multiple autoinflammatory and autoimmune diseases including type 1 diabetes, rheumatoid arthritis, Crohn's disease, and systemic lupus erythematosus (SLE) (3). The two domains of A20/TNFAIP3 cooperate to regulate NF-kB signaling. Its N-terminal ovarian tumor (OTU) domain contains a catalytic cysteine (C103) which functions as a K63 deubiquitinase, whereas the 7 zinc fingers that make up the C-terminal domain mediate K48 polyubiquitination. To regulate NF-kB signaling, A20/TNFAIP3 removes K63-polyubiquitin chains from receptor-interacting protein 1 (RIP1) and NF-kB essential modulator (NEMO), thus preventing interactions with downstream partners. A20/TNFAIP3 also contributes to the degradation of RIP1 and Ubc13 through the addition of K48 polyubiquitin chains (4).

References

1.Dixit VM1, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM. (1990) Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. J Biol Chem. 265(5):2973-8. PMID: 2406243

2.Verstrepen L, Verhelst K, van Loo G, Carpentier I, Ley SC, Beyaert R. (2010) Expression, biological activities and mechanisms of action of A20 (TNFAIP3). Biochem Pharmacol. 80(12):2009-20. PMID: 20599425

3.Mele A, Cervantes JR, Chien V, Friedman D, Ferran C. (2014) Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases. Adv Exp Med Biol. 809:163-83. PMID: 25302371

4.Das T, Chen Z, Hendriks RW, Kool M. (2018) A20/Tumor Necrosis Factor alpha-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models. Front Immunol. 9:104. PMID: 29515565

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 7128
Alternate Names
  • MGC104522
  • EC 6.3.2.-
  • TNF alpha-induced protein 3
  • EC 3.4.19.12
  • OTU domain-containing protein 7C
  • tumor necrosis factor inducible protein A20
  • Zinc finger protein A20
  • tumor necrosis factor alpha-induced protein 3
  • Putative DNA-binding protein A20
  • A20TNFA1P2
  • OTUD7CMGC138688
  • MGC138687
  • tumor necrosis factor, alpha-induced protein 3

Research Areas for A20/TNFAIP3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction

PTMs for A20/TNFAIP3

Learn more about PTMs related to A20/TNFAIP3.

Phosphorylation
Ubiquitination
Cleavage
Methylation
Glycosylation
Oxidation
Acylation

Bioinformatics Tool for A20/TNFAIP3

Discover related pathways, diseases and genes to A20/TNFAIP3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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