A-RAF Products

Antibodies
A-RAF Antibody (2G9)
A-RAF Antibody (2G9)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
A-RAF Antibody
A-RAF Antibody
NBP1-33067
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
A-RAF Antibody
A-RAF Antibody
NBP2-49479
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
A-RAF Overexpression Lysate ( ...
A-RAF Overexpression Lysate (Denat...
H00000369-T03
Applications: WB
Proteins
A-RAF Recombinant Protein
A-RAF Recombinant Protein
H00000369-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, KA
A-RAF Recombinant Protein
A-RAF Recombinant Protein
H00000369-P02
Species: Hu
Applications: WB, ELISA, PA
A-RAF Partial Recombinant Pro ...
A-RAF Partial Recombinant Protein
H00000369-Q02
Species: Hu
Applications: WB, ELISA, PA
RNAi
A-RAF RNAi
A-RAF RNAi
H00000369-R02
Species: Hu

Description

Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. A-Raf, a second member of the Raf gene family of serine/ threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of A-Raf is found at highest levels in urogenital tissues and kidney and at lowest level in brain tissue.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 369
Alternate Names
  • EC 2.7.11
  • EC 2.7.11.1
  • PKS
  • Proto-oncogene Pks
  • serine/threonine-protein kinase A-Raf
  • Proto-oncogene A-Raf-1
  • Ras-binding protein DA-Raf
  • Proto-oncogene A-Raf
  • Oncogene ARAF1
  • v-raf murine sarcoma 3611 viral oncogene homolog 1
  • PKS2A-Raf proto-oncogene serine/threonine-protein kinase
  • ARAF1A-RAF
  • RAFA1
  • v-raf murine sarcoma 3611 viral oncogene homolog

Research Areas for A-RAF

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase
Signal Transduction

Bioinformatics Tool for A-RAF

Discover related pathways, diseases and genes to A-RAF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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