A-RAF Products

Description

Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. A-Raf, a second member of the Raf gene family of serine/ threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of A-Raf is found at highest levels in urogenital tissues and kidney and at lowest level in brain tissue.

Bioinformatics

Product By Gene ID	369
Alternate Names	ARaf A-Raf ARAF1A-RAF EC 2.7.11 EC 2.7.11.1 Oncogene ARAF1 PKS PKS2 PKS2A-Raf proto-oncogene serine/threonine-protein kinase Proto-oncogene A-Raf Proto-oncogene A-Raf-1 Proto-oncogene Pks RAFA1 Ras-binding protein DA-Raf serine/threonine-protein kinase A-Raf v-raf murine sarcoma 3611 viral oncogene homolog 1 v-raf murine sarcoma 3611 viral oncogene homolog

Research Areas for A-RAF

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase
Signal Transduction