Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. A-Raf, a second member of the Raf gene family of serine/ threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of A-Raf is found at highest levels in urogenital tissues and kidney and at lowest level in brain tissue.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
369 |
| Alternate Names |
- ARAF1A-RAF
- EC 2.7.11
- EC 2.7.11.1
- Oncogene ARAF1
- PKS
- PKS2A-Raf proto-oncogene serine/threonine-protein kinase
- Proto-oncogene A-Raf
- Proto-oncogene A-Raf-1
- Proto-oncogene Pks
- RAFA1
- Ras-binding protein DA-Raf
- serine/threonine-protein kinase A-Raf
- v-raf murine sarcoma 3611 viral oncogene homolog 1
- v-raf murine sarcoma 3611 viral oncogene homolog
|
