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270-LD) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR5 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human CCL3/MIP‑1a (40 ng/mL) is neutralized (green line) by increasing concentrations of Human CCR5 Monoclonal Antibody (Catalog # MAB182). The ND50 is typically 5-20 µg/mL." class="big_lightbox" target="_blank">
C-C chemokine receptor type 5 (CCR5) is a member of the beta chemokine receptors family of integral membrane proteins. The CCR5 protein is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group.
CCR5 is a major coreceptor for human HIV infection and is predominantly expressed on T cells, macrophages, dendritic cells and microglia. It is likely that CCR5 plays a role in inflammatory responses to infection, though its exact role in normal immune function is unclear.
CCR5 antibodies are useful for HIV infection studies and research on immune responses.
![Flow Cytometry CCR5 Antibody (45531) [Unconjugated]](http://images.novusbio.com/images/antibody/CCR5_MAB182_Flow_Cytometry_22407.jpg)
![Immunohistochemistry CCR5 Antibody (45523) [Unconjugated]](http://images.novusbio.com/images/antibody/CCR5_MAB181_Immunohistochemistry_6957.jpg)
![Immunocytochemistry CCR5 Antibody (45531) [Unconjugated]](http://images.novusbio.com/images/antibody/CCR5_MAB182_Immunocytochemistry_9681.jpg)
![Neutralization CCR5 Antibody (45531) [Unconjugated]](http://images.novusbio.com/images/antibody/CCR5_MAB182_Block_Neutralize_9044.jpg)
![Immunohistochemistry CCR5 Antibody (45523) [Unconjugated]](http://images.novusbio.com/fullsize/mab181_human-ccr5-mab-clone-45523-41202412514833.jpg)
![Western Blot CCR5 Antibody (45523) [Unconjugated]](http://images.novusbio.com/fullsize/mab181_human-ccr5-mab-clone-45523-41202413392419.jpg)
![Immunohistochemistry CCR5 Antibody (45523) [Unconjugated]](http://images.novusbio.com/fullsize/mab181_human-ccr5-mab-clone-45523-4120241339240.jpg)
![Western Blot CCR5 Antibody (45523) [Unconjugated]](http://images.novusbio.com/fullsize/mab181_human-ccr5-mab-clone-45523-41202413392411.jpg)
![Immunohistochemistry CCR5 Antibody (45523) [Unconjugated]](http://images.novusbio.com/fullsize/mab181_human-ccr5-mab-clone-45523-41202413392427.jpg)
