CCR5 Products

Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	1234 Human
Uniprot	AAH38398.1 Human
Product By Gene ID	1234
Alternate Names	C-C CKR-5 C-C motif chemokine receptor 5 A159A CCCKR5 CC-CKR-5FLJ78003 CCR5 CCR-5 CD195 antigen CD195 chemokine (C-C motif) receptor 5 chemokine receptor CCR5 chemr13 CKR5 CKR-5 HIV-1 fusion coreceptor IDDM22CMKBR5C-C chemokine receptor type 5

Research Areas for CCR5

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
GPCR
Immunology
Innate Immunity