TLR9: "It Tolls for Thee"

Thu, 08/09/2012 - 12:27

Toll-like receptors (TLRs) play an essential role in the activation of innate immunity, and TLRs are expressed in a large number of immune cells like B-lymphocytes, monocytes, plasmacytoid dendritic cells and at low levels in human respiratory cells as well as in epithelial cells. Immunohistochemistry and Western blott analysis using TLR9 antibodies in several human lung cancer specimens demonstrated high levels of TLR9 expression, suggesting TLR9 may be involved in the development of lung cancer and have the potential for the treatment of malignant tumors (1). Tissue microarray and immunoflorescence analysis in glioma cell lines and human brain tissues with TLR9 antibodies also revealed high levels of TLR9 expression. TLR9 expression increases according to the histopathological grade of glioma in humans followed by proliferation and matrigel invasion (2). TLR9 has also been detected in peripheral blood mononuclear cells of canines by ELISA, Western and immunohistochemistry using TLR9 antibodies, implying that TLR9 is fairly conserved across the species (3). Novus Biologicals offers a wide range of TLR9 related products such as poly and monoclonal antibodies, recombinant proteins, ELISA kits, protein lysates and RNAi products for your research needs.

  1. PMID: 21981997
  2. PMID: 20696081
  3. PMID: 1876305

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