Synaptophysin a Marker Protein in Neuroendocrine Cells

Wed, 04/03/2013 - 08:54

Synaptophysin a Marker Protein in Neuroendocrine Cells

Synaptophysin is a major integral membrane glycoprotein of neuronal synaptic vesicles present in virtually all synapses and shows a high degree of evolutionary conservation across the mammals. Synaptophysin has been detected in numerous endocrine cell types and is localized in the membrane of small synaptic-like vesicles. Antibodies directed against synaptophysin are a valuable tool for the immunoblotting and immunohistochemical quantification.

IF analysis of Synaptophysin in PC12 cells. IF analysis of Synaptophysin in PC12 cells.

Moreover, synaptophysin is a most reliable and specific marker molecule for normal and neoplastic neuroendocrine cells in the nervous system, synaptophysin-positive tumors are known to comprise ganglioneuromas, ganglioneuroblastomas, neuroblastomas, paragangliomas and primitive neuroectodermal tumors (1). Increased levels of synaptophysin have been reported in immunoblots using anti-synaptophysin antibodies in several mouse models of Alzheimer’s disease (2). Using mono- and polyvalent antibodies against synaptophysin, a considerable number of studies from several laboratories have shown that synaptphysin is a reliable marker molecule for neuroendocrine tumors of various degrees of differentiation (3).


  1. PMID: 301030
  2. PMID: 20689242
  3. PMID: 1649612

Novus Biologicals offers a wide range of Synaptophysin reagents, including:

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