SOX-11 seals your fate

Wed, 09/03/2014 - 14:40

The SOX-11 transcription factor is a member of the SOX family known to be involved in embryonic development regulation and cell fate determination. The protein acts as a transcriptional regulator and appears to modulate fundamental aspects of normal embryonic nervous system development and tumorigenesis. SOX-11 is not found expressed in adult tissues except for the adult immature neuron. Ek's group in Sweden employed the SOX11 antibody to develop signatures comprised of mantle cell lymphoma (MCL)-associated genes through a comprehensive expression analysis of both normal and malignant B-cells1. These profiles were created to identify diagnostic and therapeutic targets that are efficient, genome-based modalities for this aggressive lymphoid malignancy. Additional studies that surveyed a wider range of lymphomas relied upon SOX11 antibody immunohistochemistry and widened the prognostic value of SOX-11 from MCL to also other lymphoblastic malignancies and Burkitt’s lymphomas2.

Immunohistochemistry-Paraffin: SOX11 Antibody Immunohistochemistry-Paraffin: SOX11 Antibody

With the SOX11 antibody, Spanish researchers were able to define the molecular criteria to allow indolent, non-treatment-requiring forms of MCL to be identified through profiling of both genome and pathology3. Gustavsson et al used the SOX11 antibody to establish a key primary role for SOX-11 as a tumor suppressor in cellular growth4. This was done through extensive siRNA knockout and ectopic expression assays. This tumor suppressor role for SOX-11 was also validated in high-grade epithelial ovarian cancers (EOCs) by Sernbo’s group, who used the SOX11 antibody to evaluate survival and methylation-dependent silencing of SOX-11 by 5-Aza-dC 5. Such epigenetic-based drugs may be powerful anti-proliferative agents in SOX-11-negative tumors.

Novus Biologicals offers SOX11 reagents for your research needs including:


  1. 16524965
  2. 19880779
  3. 20124476
  4. 20624318
  5. 21943380

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