CD45 Isoforms: Hematopoietic Differentiation, Cancer and Alzheimer's

Tue, 08/20/2013 - 16:49

CD45, also known as protein tyrosine phosphatase, receptor type, C (PTPRC), was originally known as common leukocyte antigen and is a signal transducer involved in many physiological processes such as growth and differentiation, cancer transformation, and the cell cycle. It is a transmembrane protein tyrosine phosphatase that regulates Src kinases in T- and B-cell receptor signal transduction (1). CD45 isoforms are differentially expressed within different hematopoietic cell lineages depending on their state and level of differentiation (2). CD45 has many isoforms generated through differential splicing to produce a variety of splice variants that show cell-specific patterns of expression. Studies on Alzheimer’s disease (AD) have also suggested that a CD45 isoform alteration may be a valuable diagnostic marker (3).

  1. PMID: 10700239
  2. PMID: 9566766
  3. PMID: 12417447

Novus Biologicals offers various CD45 reagents including:

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