Blogs for March 2021

Transcriptional co-activators Yap1 and Taz control growth and development

Wednesday, March 31, 2021 - 09:42
Schematic of Hippo signaling pathway highlighting Yap and Taz proteins.

By Jamshed Arslan, Pharm D, PhD

Introduction – Hippo kinase and its effectors Yap1 and Taz

Hippo signaling pathway may be regarded as a master regulator of organ growth. Hippo pathway is a sensor for cellular and tissue integrity that does not seem to have dedicated extracellular ligands or receptors. The downstream effectors of Hippo serine/threonine kinase signaling are two structurally and functionally similar proteins, Yap1 and Taz. These two proteins are transcriptional co-activators, which means that they themselves are unable to bind to the...

Untangling the contribution of the enteric nervous system to intestinal and extraintestinal disease

Thursday, March 11, 2021 - 08:42
Banner schematic showing a portion of gut and neuronal connections.

By Emily Cartwright, PhD

What is the ENS?

When it's late in the afternoon and you smell a delicious bag of popcorn in the microwave, your mouth begins to water and your stomach starts to grumble. These behaviors are a result of communication between your enteric nervous system (ENS) and brain. The ENS is an arm of the peripheral nervous system and is critically important for function of the gastrointestinal (GI) tract, controlling everything from salivation to excretion. Dysfunction of the ENS leads to...

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