By Jamshed Arslan, Pharm. D., PhD.
DNA methylation represses transcription of many genes, including tumor suppressor genes. A protein called UHRF1 recruits DNA methyltransferases (DNMTs) to establish and maintain DNA methylation. UHRF1 has several domains, most notably:
- N-terminal ubiquitin-like (UBL) domain
- TTD (tandem Tudor domain) and PHD (ubiquitin-like, containing plant homeodomain) domains that...