Species: Hu, Mu, Rt
Applications: WB, IHC, IP, MS, ICC/IF (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
WNK4 (protein kinase with no lysine 4) is a novel serine/threonine kinase which plays critical role in regulation of electrolyte homeostasis, signal transduction, survival and proliferation. WNK4 is highly expressed in kidney, colon and skin where it forms a part of tight junction complex and interacts with/activate several proteins including SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5, NEDD4L and TRPV6. It control SLC12A3 (thiazide-sensitive Na-Cl cotransporter) activity by phosphorylation process that prevents membrane trafficking of SLC12A3. WNK4 inhibits KCNJ1 (renal K+ channel) via a kinase-independent action leading to induction of protein clearance from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that controls NaCl reabsorption and K+ secretion for maintaining integrated homeostasis. Autophosphorylation of Ser-335 is essential for WNK4's activity whereas phosphorylation of Ser-331 also increase its activity. Mutations of WNK4 can cause pseudohypoaldosteronism type alpha (PHA alpha), an autosomal dominant disease characterized by hyperkalemia, metabolic acidosis and hypertension.
Bioinformatics
| Product By Gene ID |
65266 |
| Alternate Names |
- EC 2.7.11
- EC 2.7.11.1
- PHA2B
- PRKWNK4protein kinase, lysine deficient 4
- Protein kinase lysine-deficient 4
- Protein kinase with no lysine 4
- serine/threonine-protein kinase WNK4
- WNK lysine deficient protein kinase 4
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