ATR Products

Description

Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4.

Bioinformatics

Entrez	545 Human 245000 Mouse 300942 Rat
Uniprot	Q13535
Product By Gene ID	545
Alternate Names	ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3-related protein ATR EC 2.7.11.1 FRAP-related protein 1 FRP1 FRP1FRAP-related protein-1 MEC1 protein kinase ATR Rad3 related protein SCKL1 SCKLMEC1, mitosis entry checkpoint 1, homolog serine/threonine-protein kinase ATR

Research Areas for ATR

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Immunology
p53 Pathway
Virology, Bacteria and Parasites

Related ATR Blog Posts

Check out the latest blog posts on ATR.

Further unraveling the role of gamma H2AX in DNA damage response Our genome experiences a moderate amount of DNA damage in our cells on a daily basis.  This DNA damage can be in response to external environmental factors, or be a result of our internal metabolic processes going awry.  While normal rates of DNA ...    Read more.

The recent relationship of BRCA1 and 53BP1 The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage.  DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m...    Read more.

Read more ATR related blogs.