ATR Products

Description

Ataxia Telangiectasia Mutated (ATM) and Rad3- related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.

Bioinformatics

Entrez	245000 Mouse 545 Human
Uniprot	NP_001175 Human NP_444262 Human Q13535 Human
Product By Gene ID	545
Alternate Names	ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3-related protein EC 2.7.11.1 FRAP-related protein 1 FRP1FRAP-related protein-1 MEC1 protein kinase ATR Rad3 related protein SCKL1 SCKLMEC1, mitosis entry checkpoint 1, homolog serine/threonine-protein kinase ATR

Research Areas for ATR

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Immunology
p53 Pathway
Virology, Bacteria and Parasites

Related ATR Blog Posts

Check out the latest blog posts on ATR.

The recent relationship of BRCA1 and 53BP1 The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage.  DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m...    Read more.

Further unraveling the role of gamma H2AX in DNA damage response Our genome experiences a moderate amount of DNA damage in our cells on a daily basis.  This DNA damage can be in response to external environmental factors, or be a result of our internal metabolic processes going awry.  While normal rates of DNA ...    Read more.

Read more ATR related blogs.