XPF Products

Description

XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly.

Bioinformatics

Entrez	2072 Human
Uniprot	Q92889 Human
Product By Gene ID	2072
Alternate Names	DNA excision repair protein ERCC-4 DNA repair protein complementing XP-F cells EC 3.1 ERCC11 ERCC4 excision repair cross-complementing rodent repair deficiency, complementationgroup 4 xeroderma pigmentosum, complementation group F XPF XPFcomplementing defective, in Chinese hamster

Research Areas for XPF

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Nucleotide Excision Repair

Related XPF Blog Posts

Check out the latest blog posts on XPF.

NER Antibodies in Cancer Research We at Novus Biologicals have over 230 products in our antibody catalog devoted to nucleotide excision repair. NER is a multi-stage sequential process involving over 30 proteins, all of which have been widely studied. Being the primary method to repair...    Read more.

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