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Description

Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

Bioinformatics

Product By Gene ID	79840
Alternate Names	Cernunnos non-homologous end-joining factor 1 nonhomologous end-joining factor 1 Protein cernunnos XLFFLJ12610 XRCC4-like factor

Research Areas for XLF

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
DNA Repair

Related XLF Blog Posts

Check out the latest blog posts on XLF.

Ku70: The DNA's Mr. Fix-it Ku70, known by several synonyms including X-ray repair cross-complementing, 5'-deoxyribose-5-phosphate lyase Ku70 protein 6, 70 kDa subunit of Ku antigen, XRCC6, and G22P1, is a 70 kDa protein that was shown to be involved in multiple cellular pathway...    Read more.

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