TAK1 Products

Description

TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.

Bioinformatics

Entrez	22026 Mouse 26409 Mouse 313121 Rat 50659 Rat 6885 Human
Uniprot	AAH17715 Human AAH17715.1 Human BAA25025 Human NM_003188 Human NM_145331 Human NM_145332 Human NM_145333 Human NP_003179 Human NP_003179.1 Human NP_003179.1 Human NP_663304.1 Human O43318 Human P49116 Human
Product By Gene ID	6885
Alternate Names	EC 2.7.11 EC 2.7.11.25 MEKK7 mitogen-activated protein kinase kinase kinase 7 TAK1/MAP3K7 TAK1TGF1a TGF-beta activated kinase 1 TGF-beta-activated kinase 1 Transforming growth factor-beta-activated kinase 1

Research Areas for TAK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology
Innate Immunity
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway

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