Src Products

Description

Src is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state (1-3). Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity (4).

Bioinformatics

Product By Gene ID	6714
Alternate Names	ASV c-Src EC 2.7.10 EC 2.7.10.2 pp60c-src Rous sarcoma RSVgp4 Src tyrosine kinase pp60c-src tyrosine-protein kinase SRC-1 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Research Areas for Src

Find related products by research area and learn more about each of the different research areas below.

Cancer Stem Cells
Protein Kinase
Signal Transduction
Transcription Factors and Regulators
Tyrosine Kinases

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