SHP-2/PTPN11 Products

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Bioinformatics

Entrez	5781 Human
Uniprot	AAH08692 Human
Product By Gene ID	5781
Alternate Names	BPTP3 EC 3.1.3.48 MGC14433 protein tyrosine phosphatase, non-receptor type 11 protein tyrosine phosphatase-2 Protein-tyrosine phosphatase 1D Protein-tyrosine phosphatase 2C PTP1D PTP-1D PTP2C PTP-2C PTP2CNS1 PTPN11 SHP2 SHP-2 SHP2CFC SHPTP2 SH-PTP2 SH-PTP2Noonan syndrome 1 SH-PTP3 tyrosine-protein phosphatase non-receptor type 11

Research Areas for SHP-2/PTPN11

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Lipid and Metabolism
Signal Transduction
Tyrosine Kinases