Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Ch, RM, Xp
Applications: WB, IHC, KO
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Description
SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
5781 |
| Alternate Names |
- BPTP3
- EC 3.1.3.48
- MGC14433
- protein tyrosine phosphatase, non-receptor type 11
- protein tyrosine phosphatase-2
- Protein-tyrosine phosphatase 1D
- Protein-tyrosine phosphatase 2C
- PTP-1D
- PTP-2C
- PTP2CNS1
- Shp2
- SHP-2
- SHP2CFC
- SHPTP2
- SH-PTP2Noonan syndrome 1
- SH-PTP3
- tyrosine-protein phosphatase non-receptor type 11
|
![Western Blot SHP-2/PTPN11 [p Tyr542] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/SHP-2_AF3790_Western_Blot_5344.jpg)
![Simple Western SHP-2/PTPN11 [p Tyr542] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/16330.jpg)
![Immunocytochemistry SHP-2/PTPN11 [p Tyr542] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/af3790_human-mouse-phospho-shp-2-y542-affinity-purified-pab-immunocytochemistry-243202212955.jpg)
