SHIP Products

Description

SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3, 4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).

Bioinformatics

Product By Gene ID	3635
Alternate Names	145kD EC 3.1.3 hp51CNMGC142142 Inositol polyphosphate-5-phosphatase of 145 kDa inositol polyphosphate-5-phosphatase, 145kDa INPP5D MGC104855 SHIP SHIPMGC142140

Research Areas for SHIP

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Signal Transduction

Related SHIP Blog Posts

Check out the latest blog posts on SHIP.

Getting SHIP-shape Over Tumour Suppression PTEN antibodies have shown PTEN to be an important tumor suppressor and, in mutated form, a factor in cancer development. However, a recent study, led by Robert Rickert, shows that the SHIP gene may also be an important tumor suppressor in B-cell lymp...    Read more.

Read more SHIP related blogs.