TAG-72 Antibody (CC49) [PE]

• Reactivity: Hu, Rt, Bv, Ca
• Applications: IHC
• Clone: CC49
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PE

TAG-72 Antibody (CC49) [PE] Summary

• Immunogen: Purified TAG-72 protein
• Localization: Cytoplasmic and cell surface
• Specificity: Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This monoclonal antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TAG-72 Antibody (CC49) [PE]

• CA 72-4
• Protein TAG-72
• tag 72
• tag-72 Protein TAG-72

Background

Tumor-associated glycoprotein (TAG-72) is an oncofetal antigen with properties of a mucin. About 60% of carcinoma patients express TAG-72 in their sera. Majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for Ab-1 staining. Weak or no reactivity has been observed with most cell types of normal adult tissue excepting the secretory endometrium. Ab-1 is reportedly useful in distinguishing pulmonary adenocarcinomas (B72.3+) from pleural mesotheliomas (B72.3-).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for TAG-72 Antibody (NBP2-33128PE) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Eric Lee Flow Human 04/26/2022

Summary

• Application: Flow Cytometry
• Sample Tested: Human ovarian cancer cell lines
• Species: Human
• Lot: 182875

FAQs for TAG-72 Antibody (NBP2-33128PE). (Showing 1 - 1 of 1 FAQ).

1. I've used your antibodies, NBP2-33128PE, but there are no information of concentration in data sheets and vial label. Please tell me the concentration of NBP2-33128PE antibody. it's lot number is 182875.
   • For product NBP2-33128PE Lot 182875-2PABX141002-PE the concentration is 0.95mg/ml.