Recombinant SARS-CoV-2 Spike (1000-1200 a.a.) Protein

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Product Details

Summary
Concentration
LYOPH

Order Details

Recombinant SARS-CoV-2 Spike (1000-1200 a.a.) Protein Summary

Description
A recombinant partial protein with a C-Terminal His-tag and corresponding to the amino acids sequence (1000-1200) of the SARS-COV-2 Spike Protein

Source: E.coli

Protein/Peptide Type
Recombinant Protein
Purity
>90% SDS-PAGE

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Preservative
No Preservative
Concentration
LYOPH
Purity
>90% SDS-PAGE
Reconstitution Instructions
Reconstitue with 1xPBS

Alternate Names for Recombinant SARS-CoV-2 Spike (1000-1200 a.a.) Protein

  • 2019-nCoV S Protein
  • 2019-nCoV Spike
  • COVID-19 Spike
  • Human coronavirus spike glycoprotein
  • SARS-COV-2 S protein
  • SARS-COV-2 Spike glycoprotein
  • SARSCOV2 Spike protein
  • Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein
  • Spike glycoprotein
  • Spike

Background

Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). Seven coronaviruses had been found to cause human infection including SARS-CoV-2/2019-nCoV resulting in a potentially fatal atypical pneumonia, named COVID-19. SARS-CoV-2 has 4 major structural proteins including spike (S), envelope (E), membrane (M), and nucleocapsid (N), which share significant sequence homology with SARS-CoV. The spike protein in SARS-CoV-2 (1,273 aa) is a viral surface glycoprotein. Research on SARS-host protein interactions with SARS-CoV and SARS-CoV-2 viruses have shown that the viral spike (S) protein binds human ACE-2 located on the surface of mucosal cells, resulting in fusion of viral and cell membranes for viral entry. Viral entry also requires priming of the S protein by host cell proteases such as TMPRSS2, Cathepsin L or furin. The Coronavirus Spike precursor protein is processed into 2 distinct subunits with S1 (654 aa) housing the receptor binding domain (RBD) and S2 (588 aa or 458 a) facilitating membrane fusion.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for SARS-CoV-2 Spike Recombinant Protein (NBP2-90973) (0)

There are no publications for SARS-CoV-2 Spike Recombinant Protein (NBP2-90973).
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FAQs for SARS-CoV-2 Spike Recombinant Protein (NBP2-90973). (Showing 1 - 1 of 1 FAQ).

  1. I purchased "Recombinant Virus SARS-CoV-2 Spike (1000-1200 a.a.) Protein. does this freeze dried protein contain azide or Tris in it. I want to conjugate with gold nano particle & don't wan to have above mentioned chemicals
    • Looking at our records, NBP2-90973 "SARS-CoV-2 Spike (1000-1200 a.a.) protein" was lyophilised from PBS only buffer and it did not have any azide or tris in the buffer.

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