SARS-CoV-2 Spike Products

Antibodies
SARS-CoV-2 Spike Antibody
SARS-CoV-2 Spike Antibody
NBP2-41058
Species: V, V
Applications: WB, ELISA, ICC/IF, IHC-P
Host: Rabbit Polyclonal
Proteins
Recombinant SARS-CoV-2 Spike ...
Recombinant SARS-CoV-2 Spike (1000...
NBP2-90973
Recombinant SARS-CoV-2 Spike ...
Recombinant SARS-CoV-2 Spike (Acti...
10549-CV
Species: V
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant SARS-CoV Spike (G ...
Recombinant SARS-CoV Spike (GCN4-I...
10581-CV
Species: V
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). Seven coronaviruses had been found to cause human infection including SARS-CoV-2/2019-nCoV resulting in a potentially fatal atypical pneumonia, named COVID-19. SARS-CoV-2 has 4 major structural proteins including spike (S), envelope (E), membrane (M), and nucleocapsid (N), which share significant sequence homology with SARS-CoV. The spike protein in SARS-CoV-2 (1,273 aa) is a viral surface glycoprotein. Research on SARS-host protein interactions with SARS-CoV and SARS-CoV-2 viruses have shown that the viral spike (S) protein binds human ACE-2 located on the surface of mucosal cells, resulting in fusion of viral and cell membranes for viral entry. Viral entry also requires priming of the S protein by host cell proteases such as TMPRSS2, Cathepsin L or furin. The Coronavirus Spike precursor protein is processed into 2 distinct subunits with S1 (654 aa) housing the receptor binding domain (RBD) and S2 (588 aa or 458 a) facilitating membrane fusion.

Bioinformatics

Alternate Names
  • SARS-CoV-2
  • COVID-19 Spike
  • SARS-COV-2 Spike glycoprotein
  • SARSCOV2 Spike protein
  • SARS-COV-2 S protein
  • 2019-nCoV Spike
  • Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein
  • Spike glycoprotein
  • Human coronavirus spike glycoprotein
  • 2019-nCoV S Protein