Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tris-glycine, 150 mM NaCl
0.05% Sodium Azide
Protein G purified
This Polyoma Virus, Medium T Antigen antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western Blot. NB100-2749 is useful for the detection and isolation of the Middle T Antigen.
Alternate Names for Polyoma Virus, Medium T Antigen Antibody (PyMT)
Middle t antigen
Polyoma virus middle T antigen
Polyomavirus medium t antigen
Polyomavirus middle t antigen
Polyoma Viruses are a class of potentially oncogenic DNA viruses that often persist as latent infections in a host without causing disease, but may produce tumors in a host of a different species. Of particular interest, is that only the rodent Polyoma Viruses code for the production of PyMT (Medium T Antigen). This oncogenic protein of the Polyoma Virus is associated with cell membranes and interacts with a variety of cellular proteins involved in mitogenic signaling, such as tyrosine kinases c-Src, c-Yes, and Fyn. Medium T Antigen may therefore mimic the function of cellular tyrosine kinase growth factor receptors, like the platelet-derived growth factor or epidermal growth factor receptor (PMCID: PMC191984). Furthermore, it has been found that the Medium T Antigen may have a mechanism for inactivating p53, as it seems to be a characteristic of oncogenic DNA viruses (PMID: 22261839).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for Polyoma Virus, Medium T Antigen Antibody (NB100-2749)(4)
We have publications tested in 2 applications: IHC-P, IP.