Immunocytochemistry/ Immunofluorescence: Polyoma Virus, Medium T Antigen Antibody (PyMT) [NB100-2749] - PyMT-transgenic mouse mammary glands were stained in green for the PyMT protein. Staining showed good ...read more
Immunohistochemistry-Paraffin: Polyoma Virus, Medium T Antigen Antibody (PyMT) [NB100-2749] - Darpp-32 and t-Darpp expression inPpp1r1bknockout mice. Mammary tumor samples were formalin-fixed and serial sections were ...read more
Polyoma Virus. Mouse reactivity reported in multiple pieces of scientific literature.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tris-Glycine, 0.15M NaCl
0.05% Sodium Azide
Protein G purified
Alternate Names for Polyoma Virus, Medium T Antigen Antibody (PyMT)
Middle t antigen
Polyoma virus middle T antigen
Polyomavirus medium t antigen
Polyomavirus middle t antigen
Polyoma Viruses are a class of potentially oncogenic DNA viruses that often persist as latent infections in a host without causing disease, but may produce tumors in a host of a different species. Of particular interest, is that only the rodent Polyoma Viruses code for the production of PyMT (Medium T Antigen). This oncogenic protein of the Polyoma Virus is associated with cell membranes and interacts with a variety of cellular proteins involved in mitogenic signaling, such as tyrosine kinases c-Src, c-Yes, and Fyn. Medium T Antigen may therefore mimic the function of cellular tyrosine kinase growth factor receptors, like the platelet-derived growth factor or epidermal growth factor receptor (PMCID: PMC191984). Furthermore, it has been found that the Medium T Antigen may have a mechanism for inactivating p53, as it seems to be a characteristic of oncogenic DNA viruses (PMID: 22261839).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for Polyoma Virus, Medium T Antigen Antibody (NB100-2749)(13)
We have publications tested in 2 confirmed species: Mouse, Virus.
We have publications tested in 6 applications: Dual ISH-IHC, ICC/IF, IHC, IHC-P, IP, WB.
PyMT-transgenic mouse mammary glands were stained in green for the PyMT protein. Staining showed good membrane/cytoplasmic localization with moderate signal for most cells in mammary tumor. Blocking performed with 20% goat serum.
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